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In a follow up study 18 months later, creatine continued to show efficacy as a neuroprotective agent (Investigators, 2008) and it is currently in Phase III trials (NET-PDLS 2 )

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AX is a non-enzymatic and potent antioxidant that prevents chain reactions by bursting unilinear oxygen species and scavenging free radicals (Brotosudarmo et al., 2020), reducing the production of hemolymph ROS by Chinese mitten crabs ( Eriocheir sinensis ) under high pH stress (Wang et al., 2018a), inhibiting excessive hemocyte ROS production induced by high temperature stress in pufferfish ( Takifugu obscurus ) (Cheng et al., 2018), and alleviating the oxidative stress damage induced by oxidized fish-oil diet in Litopenaeus vannamei (Yu et al., 2020)